Molecular Biology

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Hake Group (Alumni)

Histone Variants and their Posttranslational Modifications


pic1Many biological processes, such as gene regulation, mitosis, DNA repair and apoptosis are regulated by alterations of chromatin structure. Several different mechanisms exist to change the structure of chromatin, thereby influencing the functional output. In this regard, we study the functional significance of novel post-translational histone modifications (PTMs) and specialized mammalian histone variants, in particular H3.1, H3.2 and H3.3, by using a variety of cell biological, biochemical and molecular biological methods.