Chromatin structure and function of eukaryotic genomes
The major functions of eukaryotic genomes – the transcription of genes, the replication of the genome and the recognition and repair of DNA damage – are governed by their organisation into chromatin. Chromatin structure is key to converting the genetic blueprint of an organism into a variety of cell type-specific epigenomes. The groups of the Molecular Biology Division at the Biomedical Center (BMC) in Munich are interested in the mechanisms, molecules and fundamental principles that underlie various aspects of chromatin structure and epigenome function. We are interested in how functional states derive from the interplay of opposing principles: those that endow chromatin structures with plasticity and enable a cell to respond to developmental, metabolic and environmental signals, and others, promoting the assembly of lasting, heritable structures that organise chromosomes and define cellular identity.
The Principal Investigators of ‘Molecular Biology’ at BMC: (from left):
Felix Müller-Planitz, Christoph Kurat, Philipp Korber, Peter B. Becker,
Gunnar Schotta, Axel Imhof, Ralph Rupp.