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selected publications:

Schubert T, Pusch MC, Diermeier S, Benes V, Kremmer E, Imhof A, Längst G. Df31 Protein and snoRNAs Maintain Accessible Higher-Order Structures of Chromatin.Mol Cell. 2012 Sep 25.[Epub ahead of print]

Forné I, Ludwigsen J, Imhof A, Becker PB, Mueller-Planitz F. Probing the conformation of the ISWI ATPase domain with genetically encoded photoreactive crosslinkers and mass spectrometry. Mol Cell Proteomics. 2011 Dec 13. [Epub ahead of print]

Scharf, A.N.D, Barth, T.K. and Imhof,A. (2009).Establishment of Histone Modifications after Chromatin Assembly. Nucleic Acids Res. 2009 Aug;37(15):5032-40. Epub 2009 Jun 18.

Scharf A.N.D, Meier K, Seitz V, Kremmer E, Brehm A, Imhof A: Monomethylation of lysine 20 on histone H4 facilitates chromatin maturation. Mol Cell Biol 2008.

Greiner D, Bonaldi T, Eskeland R, Roemer E, Imhof A: Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Nat Chem Biol 2005, 1(3):143-145.

 

recent publications:

Bioinformatic analysis of proteomics data. Schmidt A, Forne I, Imhof A. BMC Syst Biol. 2014 Mar 13;8(Suppl 2):S3. Epub 2014 Mar 13.

Epigenetic reprogramming of cortical neurons through alteration of dopaminergic circuits. Brami-Cherrier K, Anzalone A, Ramos M, Forne I, Macciardi F, Imhof A, Borrelli E. Mol Psychiatry. 2014 Jul 15. doi: 10.1038/mp.2014.67.

Identification of novel Drosophila centromere associated proteins. Barth TK, Schade GO, Schmidt A, Vetter I, Wirth M, Heun P, Thomae AW, Imhof A. Proteomics. 2014 May 19. doi: 10.1002/pmic.201400052.

The histone variant H2A.Bbd is enriched at sites of DNA synthesis. Sansoni V, Casas-Delucchi CS, Rajan M, Schmidt A, Bönisch C, Thomae AW, Staege MS, Hake SB, Cardoso MC, Imhof A. Nucleic Acids Res. 2014;42(10):6405-20.

Heterogeneous Antibody-Based Activity Assay for Lysine Specific Demethylase 1 (LSD1) on a Histone Peptide Substrate. Schmitt ML, Ladwein KI, Carlino L, Schulz-Fincke J, Willmann D, Metzger E, Schilcher P, Imhof A, Schüle R, Sippl W, Jung M. J Biomol Screen. 2014 Mar 31.

Mislocalization of the Centromeric Histone Variant CenH3/CENP-A in Human Cells Depends on the Chaperone DAXX Lacoste, N., Woolfe, A., Tachiwana, H., Garea, A.V., Barth, T., Cantaloube, S., Kurumizaka, H., Imhof, A., and Almouzni, G. (2014). Mol. Cell 53, 631–644.

Circadian Control of Fatty Acid Elongation by SIRT1-mediated Deacetylation of Acetyl-CoA Synthetase 1.Sahar S, Masubuchi S, Eckel-Mahan K, Vollmer S, Galla L, Ceglia N, Masri S, Barth TK, Grimaldi B, Oluyemi O, Astarita G, Hallows WC, Piomelli D, Imhof A, Baldi P, Denu JM, Sassone-Corsi P. J Biol Chem. 2014 Jan 14.

Epstein Barr Virus-mediated transformation of B cells induces global chromatin changes independent to the acquisition of proliferation. Hernando H, Islam A, Rodriguez-Ubreva J, Forne I, Ciudad L, Imhof A, Shannon-Lowe C, Ballestar E. Nucleic Acids Research 2014 Jan 7;42(1):249-63.

Schubert T, Pusch MC, Diermeier S, Benes V, Kremmer E, Imhof A, Längst G. Df31 Protein and snoRNAs Maintain Accessible Higher-Order Structures of Chromatin.Mol Cell. 2012 Sep 25.[Epub ahead of print]

Forné I, Ludwigsen J, Imhof A, Becker PB, Mueller-Planitz F. Probing the conformation of the ISWI ATPase domain with genetically encoded photoreactive crosslinkers and mass spectrometry. Mol Cell Proteomics. 2011 Dec 13. [Epub ahead of print]

Villar-Garea A, Forne I, Vetter I, Kremmer E, Thomae A, Imhof A. Developmental regulation of N-terminal H2B methylation in Drosophila melanogaster.Nucleic Acids Res. 2011 Nov 3. [Epub ahead of print]

Barth TK, Imhof A. Fast signals and slow marks: the dynamics of histone modifications. Trends Biochem Sci. 2010 Aug 2. [Epub ahead of print]

Metzger E, Imhof A, Patel D, Kahl P, Hoffmeyer K, Friedrichs N, Müller JM, Greschik H, Kirfel J, Ji S, Kunowska N, Beisenherz-Huss C, Günther T, Buettner R, Schüle R. Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. Nature. 2010 Apr 1;464(7289):792-6. Epub 2010 Mar 14.

Jasencakova Z, Scharf AN, Ask K, Corpet A, Imhof A, Almouzni G, Groth A. Replication stress interferes with histone recycling and predeposition marking of new histones. Mol Cell. 2010 Mar 12;37(5):736-43.

Boeke J, Regnard C, Cai W, Johansen J, Johansen KM, Becker PB, Imhof A. Phosphorylation of SU(VAR)3-9 by the chromosomal kinase JIL-1.PLoS One. 2010 Apr 6;5(4):e10042.

Lavigne M, Eskeland R, Azebi S, Saint-André V, Jang SM, Batsché E, Fan HY, Kingston RE, Imhof A, Muchardt C. Interaction of HP1 and Brg1/Brm with the globular domain of histone H3 is required for HP1-mediated repression. PLoS Genet. 2009 Dec;5(12):e1000769. Epub .

Scharf, A.N.D, Barth, T.K. and Imhof,A. (2009).Establishment of Histone Modifications after Chromatin Assembly. Nucleic Acids Res. 2009 Aug;37(15):5032-40. Epub 2009 Jun 18.

Abel, J., Eskeland, R., Raffa, G.D., Kremmer, E., and Imhof, A. (2009). Drosophila HP1c is regulated by an auto-regulatory feedback loop through its binding partner Woc. PLoS ONE 4, e5089.

Villar-Garea A, Israel L, Imhof A: Analysis of histone modifications by mass spectrometry. Curr Protoc Protein Sci 2008, Chapter 14:Unit 14 10.

Villar-Garea A, Imhof A: Fine mapping of posttranslational modifications of the linker histone H1 from Drosophila melanogaster. PLoS ONE 2008, 3(2):e1553.

Scharf AN, Meier K, Seitz V, Kremmer E, Brehm A, Imhof A: Monomethylation of lysine 20 on histone H4 facilitates chromatin maturation. Mol Cell Biol 2008.

Ohno K, McCabe D, Czermin B, Imhof A, Pirrotta V: ESC, ESCL and their roles in Polycomb Group mechanisms. Mech Dev 2008, 125(5-6):527-541.

Zu XL, Besant PG, Imhof A, Attwood PV: Mass spectrometric analysis of protein histidine phosphorylation. Amino Acids 2007, 32(3):347-357.

Yuan X, Feng W, Imhof A, Grummt I, Zhou Y: Activation of RNA polymerase I transcription by cockayne syndrome group B protein and histone methyltransferase G9a. Mol Cell 2007, 27(4):585-595.

Villar-Garea A, Griese M, Imhof A: Biomarker discovery from body fluids using mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2007, 849(1-2):105-114.

Trasak C, Zenner G, Vogel A, Yuksekdag G, Rost R, Haase I, Fischer M, Israel L, Imhof A, Linder S et al: Yersinia protein kinase YopO is activated by a novel G-actin binding process. J Biol Chem 2007, 282(4):2268-2277.

Pauly B, Lasi M, MacKintosh C, Morrice N, Imhof A, Regula J, Rudd S, David CN, Bottger A: Proteomic screen in the simple metazoan Hydra identifies 14-3-3 binding proteins implicated in cellular metabolism, cytoskeletal organisation and Ca2+ signalling. BMC Cell Biol 2007, 8:31.

Kuhn PH, Marjaux E, Imhof A, De Strooper B, Haass C, Lichtenthaler SF: Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase. J Biol Chem 2007, 282(16):11982-11995.

Hyllus D, Stein C, Schnabel K, Schiltz E, Imhof A, Dou Y, Hsieh J, Bauer UM: PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation. Genes Dev 2007, 21(24):3369-3380.

Ferreira R, Eberharter A, Bonaldi T, Chioda M, Imhof A, Becker PB: Site-specific acetylation of ISWI by GCN5. BMC Mol Biol 2007, 8:73.

Eskeland R, Eberharter A, Imhof A: HP1 binding to chromatin methylated at H3K9 is enhanced by auxiliary factors. Mol Cell Biol 2007, 27(2):453-465.

Duvezin-Caubet S, Koppen M, Wagener J, Zick M, Israel L, Bernacchia A, Jagasia R, Rugarli EI, Imhof A, Neupert W et al: OPA1 processing reconstituted in yeast depends on the subunit composition of the m-AAA protease in mitochondria. Mol Biol Cell 2007, 18(9):3582-3590.

Bell O, Wirbelauer C, Hild M, Scharf AN, Schwaiger M, MacAlpine DM, Zilbermann F, van Leeuwen F, Bell SP, Imhof A et al: Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila. EMBO J 2007, 26(24):4974-4984.

Villar-Garea A, Imhof A: The analysis of histone modifications. Biochim Biophys Acta 2006, 1764(12):1932-1939.

Stabell M, Eskeland R, Bjorkmo M, Larsson J, Aalen RB, Imhof A, Lambertsson A: The Drosophila G9a gene encodes a multi-catalytic histone methyltransferase required for normal development. Nucleic Acids Res 2006, 34(16):4609-4621.

Schmoldt S, Latzin P, Heesemann J, Griese M, Imhof A, Hogardt M: Clonal analysis of Inquilinus limosus isolates from six cystic fibrosis patients and specific serum antibody response. J Med Microbiol 2006, 55(Pt 10):1425-1433.

Schmitt S, Prokisch H, Schlunck T, Camp DG, 2nd, Ahting U, Waizenegger T, Scharfe C, Meitinger T, Imhof A, Neupert W et al: Proteome analysis of mitochondrial outer membrane from Neurospora crassa. Proteomics 2006, 6(1):72-80.

Loyola A, Bonaldi T, Roche D, Imhof A, Almouzni G: PTMs on H3 variants before chromatin assembly potentiate their final epigenetic state. Mol Cell 2006, 24(2):309-316.

Imhof A: Epigenetic regulators and histone modification. Brief Funct Genomic Proteomic 2006, 5(3):222-227.

Fluhrer R, Grammer G, Israel L, Condron MM, Haffner C, Friedmann E, Bohland C, Imhof A, Martoglio B, Teplow DB et al: A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. Nat Cell Biol 2006, 8(8):894-896.

Bauer R, Imhof A: Lipids join the post-genomic era. Genome Biol 2006, 7(10):330.

Taipale M, Rea S, Richter K, Vilar A, Lichter P, Imhof A, Akhtar A: hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells. Mol Cell Biol 2005, 25(15):6798-6810.

Imhof A, Bonaldi T: "Chromatomics" the analysis of the chromatome. Mol Biosyst 2005, 1(2):112-116.

Greiner D, Bonaldi T, Eskeland R, Roemer E, Imhof A: Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Nat Chem Biol 2005, 1(3):143-145.

Fraga MF, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, Schotta G, Bonaldi T, Haydon C, Ropero S, Petrie K et al: Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet 2005, 37(4):391-400.

Grimminger V, Richter K, Imhof A, Buchner J, Walter S: The prion curing agent guanidinium chloride specifically inhibits ATP hydrolysis by Hsp104. J Biol Chem 2004, 279(9):7378-7383.

Eskeland R, Czermin B, Boeke J, Bonaldi T, Regula JT, Imhof A: The N-terminus of Drosophila SU(VAR)3-9 mediates dimerization and regulates its methyltransferase activity. Biochemistry 2004, 43(12):3740-3749.

Bonaldi T, Regula JT, Imhof A: The use of mass spectrometry for the analysis of histone modifications. Methods Enzymol 2004, 377:111-130.

Bonaldi T, Imhof A, Regula JT: A combination of different mass spectroscopic techniques for the analysis of dynamic changes of histone modifications. Proteomics 2004, 4(5):1382-1396.

Imhof A: Histone modifications: an assembly line for active chromatin? Curr Biol 2003, 13(1):R22-24.

Imhof A: Histone modifications--marks for gene expression? Adv Exp Med Biol 2003, 544:169-180.

Czermin B, Imhof A: The sounds of silence--histone deacetylation meets histone methylation. Genetica 2003, 117(2-3):159-164.

Czermin B, Melfi R, McCabe D, Seitz V, Imhof A, Pirrotta V: Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell 2002, 111(2):185-196.

Bouazoune K, Mitterweger A, Langst G, Imhof A, Akhtar A, Becker PB, Brehm A: The dMi-2 chromodomains are DNA binding modules important for ATP-dependent nucleosome mobilization. EMBO J 2002, 21(10):2430-2440.

Beisel C, Imhof A, Greene J, Kremmer E, Sauer F: Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1. Nature 2002, 419(6909):857-862.