Epigenetic Gene Regulation
Epigenetic mechanisms regulate multiple aspects of normal development (stem cell maintenance, differentiation). Misregulation of epigenetic programs can result in aberrant development (cancer, aging). In this context we study the mechanisms of epigenetic gene regulation using a combination of mouse genetics (knock-out and knock-in mouse models), cell biology (embryonic stem cells, differentiation systems, CrispR/Cas, genome-wide sgRNA screens) and biochemical (ChIP-seq, RNA-seq, MeDIP-seq, ATAC-seq, etc.) approaches.