Molecular Biology

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Peer-reviewed research articles
Harrer, N., Schindler, C.E.M., Bruetzel, L.K., Forne, I., Ludwigsen, J., Imhof, A., Zacharias, M., Lipfert, J.*, Mueller-Planitz, F.* (2018). Structural Architecture of the Nucleosome Remodeler ISWI Determined from Cross-Linking, Mass Spectrometry, SAXS, and Modeling. Structure 26, 282-294.e286.

Singh H.R., Nardozza A.P., Möller I.R., Knobloch, G., Kistemaker H.A.V., Hassler M., Harrer N., Blessing, C., Eustermann, S., Kotthoff C., Huet S., Müller-Planitz F., Filippov D., Timinszky G., Rand K.D., Ladurner A.G. (2017). A poly-ADP-ribose trigger releases the autoinhibition of a chromatin remodeling oncogene. Mol Cell 68, 860-871 e867.

Stepp W.L., Merck G., Mueller-Planitz F., Ökten Z. (2017). Kinesin-2 motors adapt their stepping behavior for processive transport on axonemes and microtubules. EMBO Rep 18, 1947-1956.

Oberhofer, A., Spieler, P., Rosenfeld, Y., Stepp, W.L., Cleetus, A., Hume, A.N., Mueller-Planitz, F.*, and Okten, Z.* (2017). Phosphorylation regulates melanophilin’s competitive binding to the microtubule and actin networks in vitro. Proc Natl Acad Sci U S A 114(24): E4714-E4723.

Ludwigsen J., Pfennig S., Singh A.K., Schindler C., Harrer N., Forne I., Zacharias M., Mueller-Planitz F.* (2017). Concerted regulation of ISWI by its N-terminal region and the histone H4 N-terminal tail. eLife, 6.

Lieleg C., Ketterer P., Nuebler J., Ludwigsen J., Gerland U., Dietz H., Mueller-Planitz F. *, Korber P.* (2015). Nucleosome spacing generated by ISWI and CHD1 remodelers is constant regardless of nucleosome density. Mol Cell Biol, 35(9), 1588-605.

Mueller-Planitz, F.* (2015). Crossfinder-assisted mapping of protein crosslinks formed by site-specifically incorporated crosslinkers. Bioinformatics, doi: 10.1093/bioinformatics/btv083.

Klinker, H., Haas, C., Harrer, N., Becker, P.B. and Mueller-Planitz, F.* (2014). Rapid purification of recombinant histones. PLoS One, 9:e104029.

Klinker, H., Mueller-Planitz, F., Yang, R., Forné, I., Liu, C.F., Nordenskiold, L. and Becker, P.B. (2014) ISWI Remodelling of Physiological Chromatin Fibres Acetylated at Lysine 16 of Histone H4. PLoS One, 9, e88411.

Ludwigsen, J., Klinker, H. and Mueller-Planitz, F.* (2013). No need for a power stroke in ISWI-mediated nucleosome sliding. EMBO Rep 14, 1092-1097.

Mueller-Planitz, F.*, Klinker, H., Ludwigsen, J., and Becker, P.B.* (2013). The ATPase domain of ISWI is an autonomous nucleosome remodeling machine. Nat Struct Mol Biol 20, 82-89.

Gazda, L., Pokrzywa, W., Hellerschmied, D., Lowe, T., Forné, I., Mueller-Planitz, F., Hoppe, T., and Clausen, T. (2013). The Myosin Chaperone UNC-45 Is Organized in Tandem Modules to Support Myofilament Formation in C. elegans. Cell 152, 183-195.

Forné, I., Ludwigsen, J., Imhof, A., Becker, P.B., and Mueller-Planitz, F.* (2012). Probing the conformation of the ISWI ATPase domain with genetically encoded photoreactive crosslinkers and mass spectrometry. Mol Cell Proteomics 11, M111 012088.

Brunnbauer, M., Mueller-Planitz, F., Kosem, S., Ho, T.H., Dombi, R., Gebhardt, J.C., Rief, M., and Okten, Z. (2010). Regulation of a heterodimeric kinesin-2 through an unprocessive motor domain that is turned processive by its partner. Proc Natl Acad Sci U S A 107, 10460-10465.

Fauth, T., Müller-Planitz, F., Konig, C., Straub, T., and Becker, P.B. (2010). The DNA binding CXC domain of MSL2 is required for faithful targeting the Dosage Compensation Complex to the X chromosome. Nucleic Acids Res 38, 3209-3221.

Mueller-Planitz, F., and Herschlag, D. (2008). Coupling between ATP binding and DNA cleavage by DNA topoisomerase II: A unifying kinetic and structural mechanism. J Biol Chem 283, 17463-17476.

Mueller-Planitz, F., and Herschlag, D. (2007). DNA topoisomerase II selects DNA cleavage sites based on reactivity rather than binding affinity. Nucleic Acids Res 35, 3764-3773.

Mueller-Planitz, F., and Herschlag, D. (2006). Interdomain communication in DNA topoisomerase II. DNA binding and enzyme activation. J Biol Chem 281, 23395-23404.

Method papers and reviews

Ludwigsen, J., Hepp, N., Klinker, H., Pfennig, S., Mueller-Planitz, F.* Remodeling and repositioning of nucleosomes in nucleosomal arrays. Methods Mol Biol 1805, 349-370.

Mueller-Planitz, F.*, Klinker, H. and Becker, P.B.* (2013). Nucleosome sliding mechanisms: new twists in a looped history. Nat Struct Mol Biol, 20, 1026-1032.